iMapSplice: Alleviating reference bias through personalized RNA-seq alignment.

Genomic variants in both coding and non-coding sequences can have functionally important and sometimes deleterious effects on exon splicing of gene transcripts. For transcriptome profiling using RNA-seq, the accurate alignment of reads across exon junctions is a critical step. Existing algorithms th...

Full description

Bibliographic Details
Main Authors: Xinan Liu, James N MacLeod, Jinze Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6086400?pdf=render

Similar Items