Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals

Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals

Microsporidia are obligate intracellular and eukaryotic pathogens that can infect immunocompromised and immunocompetent mammals, including humans. Both innate and adaptive immune systems play important roles against microsporidian infection. The innate immune system can partially eliminate the infec...

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Main Authors: Yinze Han, Hailong Gao, Jinzhi Xu, Jian Luo, Bing Han, Jialing Bao, Guoqing Pan, Tian Li, Zeyang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
microsporidia
mammal host
immune response
innate immunity
adaptive immunity
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01468/full
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spelling doaj-db3eaaa01a804296b4369474b459e8e32020-11-25T03:14:54ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-06-011110.3389/fmicb.2020.01468497942Innate and Adaptive Immune Responses Against Microsporidia Infection in MammalsYinze Han0Yinze Han1Hailong Gao2Hailong Gao3Jinzhi Xu4Jinzhi Xu5Jian Luo6Jian Luo7Bing Han8Jialing Bao9Jialing Bao10Guoqing Pan11Guoqing Pan12Tian Li13Tian Li14Zeyang Zhou15Zeyang Zhou16Zeyang Zhou17State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaDepartment of Pathology, Albert Einstein College of Medicine, The Bronx, NY, United StatesState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaChongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, ChinaCollege of Life Sciences, Chongqing Normal University, Chongqing, ChinaMicrosporidia are obligate intracellular and eukaryotic pathogens that can infect immunocompromised and immunocompetent mammals, including humans. Both innate and adaptive immune systems play important roles against microsporidian infection. The innate immune system can partially eliminate the infection by immune cells, such as gamma delta T cell, natural killer cells (NKs), macrophages and dendritic cells (DCs), and present the pathogens to lymphocytes. The innate immune cells can also prime and enhance the adaptive immune response via surface molecules and secreted cytokines. The adaptive immune system is critical to eliminate microsporidian infection by activating cytotoxic T lymphocyte (CTL) and humoral immune responses, and feedback regulation of the innate immune mechanism. In this review, we will discuss the cellular and molecular responses and functions of innate and adaptive immune systems against microsporidian infection.https://www.frontiersin.org/article/10.3389/fmicb.2020.01468/fullmicrosporidiamammal hostimmune responseinnate immunityadaptive immunity
collection DOAJ
language English
format Article
sources DOAJ
author Yinze Han
Yinze Han
Hailong Gao
Hailong Gao
Jinzhi Xu
Jinzhi Xu
Jian Luo
Jian Luo
Bing Han
Jialing Bao
Jialing Bao
Guoqing Pan
Guoqing Pan
Tian Li
Tian Li
Zeyang Zhou
Zeyang Zhou
Zeyang Zhou
spellingShingle Yinze Han
Yinze Han
Hailong Gao
Hailong Gao
Jinzhi Xu
Jinzhi Xu
Jian Luo
Jian Luo
Bing Han
Jialing Bao
Jialing Bao
Guoqing Pan
Guoqing Pan
Tian Li
Tian Li
Zeyang Zhou
Zeyang Zhou
Zeyang Zhou
Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
Frontiers in Microbiology
microsporidia
mammal host
immune response
innate immunity
adaptive immunity
author_facet Yinze Han
Yinze Han
Hailong Gao
Hailong Gao
Jinzhi Xu
Jinzhi Xu
Jian Luo
Jian Luo
Bing Han
Jialing Bao
Jialing Bao
Guoqing Pan
Guoqing Pan
Tian Li
Tian Li
Zeyang Zhou
Zeyang Zhou
Zeyang Zhou
author_sort Yinze Han
title Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
title_short Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
title_full Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
title_fullStr Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
title_full_unstemmed Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
title_sort innate and adaptive immune responses against microsporidia infection in mammals
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2020-06-01
description Microsporidia are obligate intracellular and eukaryotic pathogens that can infect immunocompromised and immunocompetent mammals, including humans. Both innate and adaptive immune systems play important roles against microsporidian infection. The innate immune system can partially eliminate the infection by immune cells, such as gamma delta T cell, natural killer cells (NKs), macrophages and dendritic cells (DCs), and present the pathogens to lymphocytes. The innate immune cells can also prime and enhance the adaptive immune response via surface molecules and secreted cytokines. The adaptive immune system is critical to eliminate microsporidian infection by activating cytotoxic T lymphocyte (CTL) and humoral immune responses, and feedback regulation of the innate immune mechanism. In this review, we will discuss the cellular and molecular responses and functions of innate and adaptive immune systems against microsporidian infection.
topic microsporidia
mammal host
immune response
innate immunity
adaptive immunity
url https://www.frontiersin.org/article/10.3389/fmicb.2020.01468/full
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