Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids

Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids

The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3–22.7% <i>w/w</i>, (ii) lipid...

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Bibliographic Details
Main Authors:	Ruba Almasri, Paul Joyce, Hayley B. Schultz, Nicky Thomas, Kristen E. Bremmell, Clive A. Prestidge
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Pharmaceutics
Subjects:	supersaturation silica-lipid hybrid spray drying lipolysis lipid-based formulation fenofibrate
Online Access:	https://www.mdpi.com/1999-4923/12/7/687

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