Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

Background: Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that suppression of PERK-ATF4-CHOP pathway by Astragaloside IV (AS-IV) is associated with inhibition of ER stress-induced pod...

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Bibliographic Details
Main Authors: Yifang Chen, Dingkun Gui, Jianguo Chen, Dongyuan He, Yunling Luo, Niansong Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Astragaloside IV
Endoplasmic reticulum stress
PERK-ATF4-CHOP pathway
Podocyte apoptosis
Diabetic nephropathy
Online Access:http://www.karger.com/Article/FullText/362974

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