Coping with centriole loss: pericentriolar material maintenance after centriole degeneration

Coping with centriole loss: pericentriolar material maintenance after centriole degeneration

Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Fe...

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Main Authors: Carla M. C. Abreu, Tiago J. Dantas
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02243-6
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spelling doaj-db20c04dfa23459780a3f89f3348458e2021-06-13T11:33:55ZengNature Publishing GroupCommunications Biology2399-36422021-06-01411210.1038/s42003-021-02243-6Coping with centriole loss: pericentriolar material maintenance after centriole degenerationCarla M. C. Abreu0Tiago J. Dantas1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Portoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do PortoShortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Feldman groups now show that not only does the PCM persist at the ciliary base, it also continues to assemble in the absence of canonical centrioles. Importantly, these neuronal centrosomes retain the ability to function as the cell’s main microtubule-organizing center and support ciliary function.https://doi.org/10.1038/s42003-021-02243-6
collection DOAJ
language English
format Article
sources DOAJ
author Carla M. C. Abreu
Tiago J. Dantas
spellingShingle Carla M. C. Abreu
Tiago J. Dantas
Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
Communications Biology
author_facet Carla M. C. Abreu
Tiago J. Dantas
author_sort Carla M. C. Abreu
title Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_short Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_full Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_fullStr Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_full_unstemmed Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
title_sort coping with centriole loss: pericentriolar material maintenance after centriole degeneration
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Feldman groups now show that not only does the PCM persist at the ciliary base, it also continues to assemble in the absence of canonical centrioles. Importantly, these neuronal centrosomes retain the ability to function as the cell’s main microtubule-organizing center and support ciliary function.
url https://doi.org/10.1038/s42003-021-02243-6
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