Functional characterization of human Cd33<sup>+ </sup>And Cd11b<sup>+ </sup>myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

Functional characterization of human Cd33<sup>+ </sup>And Cd11b<sup>+ </sup>myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

<p>Abstract</p> <p>Background</p> <p>Tumor immune tolerance can derive from the recruitment of suppressor cell populations, including myeloid-derived suppressor cells (MDSC). In cancer patients, MDSC accumulation correlates with increased tumor burden, but the mechanism...

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Bibliographic Details
Main Authors: Arger Nicholas, Bingham Brigid, Russell Sarah M, Megiel Carolina, Lechner Melissa G, Woo Tammy, Epstein Alan L
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Journal of Translational Medicine
Subjects:
myeloid-derived suppressor cells
tumor immune tolerance
human tumor cell lines
immunomodulation
cytokines
hypoxia-inducible factor 1 alpha
CAAAT-enhancer binding protein
signal transducer and activator of transcription
inflammation
Online Access:http://www.translational-medicine.com/content/9/1/90

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