Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase

Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase

The liver toxicity of valproic acid (VPA) is an established side effect of this widely used antiepileptic drug, which is extremely problematic for patients with metabolic epilepsy and particularly epilepsy due to mitochondrial dysfunction. In the present report, we investigated the reason for liver...

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Bibliographic Details
Main Authors: Alexei P. Kudin, Hafiz Mawasi, Arik Eisenkraft, Christian E. Elger, Meir Bialer, Wolfram s. Kunz
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
valproic acid
analogues of valproic acid
liver toxicity
metabolic epilepsy
mitochondrial epilepsy
Online Access:https://www.mdpi.com/1422-0067/18/9/1912

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