Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat

Endomorphin-2 Decreases Excitatory Synaptic Transmission in the Spinal Ventral Horn of the Rat

Motor impairment is one of the serious side-effects of morphine, which is an exogenous agonist of the μ-opioid receptor (MOR) as well as a widely used analgesic drug in clinical practice for chronic pain treatment. Endomorphins (EMs, including EM-1 and EM-2), the most effective and specific endogeno...

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Bibliographic Details
Main Authors: Zhen-Yu Wu, Ya-Cheng Lu, Ban Feng, Ying-Biao Chen, Yang Bai, Ting Zhang, Hua Zhang, Tao Chen, Yu-Ling Dong, Hui Li, Yun-Qing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neural Circuits
Subjects:
endomorphin-2
μ-opioid receptor
motor impairment
motoneuron
synapse
sEPSC
Online Access:http://journal.frontiersin.org/article/10.3389/fncir.2017.00055/full

Internet

http://journal.frontiersin.org/article/10.3389/fncir.2017.00055/full

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