Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent

Autoimmune encephalitic syndromes include mutism, somnolence, movement disorder, and behavioral, or psychiatric symptoms. When paired with bilateral basal ganglia lesions on magnetic resonance imaging, these support the diagnosis of basal ganglia encephalitis (BGE). BGE is a rare but distinct entity...

Full description

Bibliographic Details
Main Authors:	Xuejiao Dai, Lilu Kuang, Li Feng, Xiaoping Yi, Weiting Tang, Qiao Liao, Xiaoyan Long, Junling Wang, Jing Li, Huan Yang, Bo Xiao, Guoliang Li, Si Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Neurology
Subjects:	D2R basal ganglia encephalitis adolescent movement disorder psychiatric
Online Access:	https://www.frontiersin.org/article/10.3389/fneur.2020.00471/full

id	doaj-daec89eb45c242be9753dc38a21d07da
record_format	Article
spelling	doaj-daec89eb45c242be9753dc38a21d07da2020-11-25T03:29:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00471528701Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in AdolescentXuejiao Dai0Xuejiao Dai1Lilu Kuang2Lilu Kuang3Li Feng4Xiaoping Yi5Weiting Tang6Qiao Liao7Xiaoyan Long8Junling Wang9Jing Li10Huan Yang11Bo Xiao12Guoliang Li13Si Chen14Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Liuyang Jili Hospital, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaAutoimmune encephalitic syndromes include mutism, somnolence, movement disorder, and behavioral, or psychiatric symptoms. When paired with bilateral basal ganglia lesions on magnetic resonance imaging, these support the diagnosis of basal ganglia encephalitis (BGE). BGE is a rare but distinct entity of putative autoimmune etiology, with specific basal ganglia inflammation and acute movement disorders. A previous study identified dopamine-2 receptors (D2R) antibody to be positive in most BGE children, indicating that the D2R antibody may trigger the downstream pathological process in BGE patients. The highest levels of D2R are found in the striatum, the nucleus accumbens, and the olfactory tubercle. D2R antibody-positive BGE is widely reported in children. Here we present a 17-year-old girl with a typical clinical feature of basal ganglia encephalitis, who benefited from immune therapy.https://www.frontiersin.org/article/10.3389/fneur.2020.00471/fullD2Rbasal ganglia encephalitisadolescentmovement disorderpsychiatric
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xuejiao Dai Xuejiao Dai Lilu Kuang Lilu Kuang Li Feng Xiaoping Yi Weiting Tang Qiao Liao Xiaoyan Long Junling Wang Jing Li Huan Yang Bo Xiao Guoliang Li Si Chen
spellingShingle	Xuejiao Dai Xuejiao Dai Lilu Kuang Lilu Kuang Li Feng Xiaoping Yi Weiting Tang Qiao Liao Xiaoyan Long Junling Wang Jing Li Huan Yang Bo Xiao Guoliang Li Si Chen Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent Frontiers in Neurology D2R basal ganglia encephalitis adolescent movement disorder psychiatric
author_facet	Xuejiao Dai Xuejiao Dai Lilu Kuang Lilu Kuang Li Feng Xiaoping Yi Weiting Tang Qiao Liao Xiaoyan Long Junling Wang Jing Li Huan Yang Bo Xiao Guoliang Li Si Chen
author_sort	Xuejiao Dai
title	Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
title_short	Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
title_full	Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
title_fullStr	Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
title_full_unstemmed	Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
title_sort	anti-dopamine receptor 2 antibody-positive encephalitis in adolescent
publisher	Frontiers Media S.A.
series	Frontiers in Neurology
issn	1664-2295
publishDate	2020-06-01
description	Autoimmune encephalitic syndromes include mutism, somnolence, movement disorder, and behavioral, or psychiatric symptoms. When paired with bilateral basal ganglia lesions on magnetic resonance imaging, these support the diagnosis of basal ganglia encephalitis (BGE). BGE is a rare but distinct entity of putative autoimmune etiology, with specific basal ganglia inflammation and acute movement disorders. A previous study identified dopamine-2 receptors (D2R) antibody to be positive in most BGE children, indicating that the D2R antibody may trigger the downstream pathological process in BGE patients. The highest levels of D2R are found in the striatum, the nucleus accumbens, and the olfactory tubercle. D2R antibody-positive BGE is widely reported in children. Here we present a 17-year-old girl with a typical clinical feature of basal ganglia encephalitis, who benefited from immune therapy.
topic	D2R basal ganglia encephalitis adolescent movement disorder psychiatric
url	https://www.frontiersin.org/article/10.3389/fneur.2020.00471/full
work_keys_str_mv	AT xuejiaodai antidopaminereceptor2antibodypositiveencephalitisinadolescent AT xuejiaodai antidopaminereceptor2antibodypositiveencephalitisinadolescent AT lilukuang antidopaminereceptor2antibodypositiveencephalitisinadolescent AT lilukuang antidopaminereceptor2antibodypositiveencephalitisinadolescent AT lifeng antidopaminereceptor2antibodypositiveencephalitisinadolescent AT xiaopingyi antidopaminereceptor2antibodypositiveencephalitisinadolescent AT weitingtang antidopaminereceptor2antibodypositiveencephalitisinadolescent AT qiaoliao antidopaminereceptor2antibodypositiveencephalitisinadolescent AT xiaoyanlong antidopaminereceptor2antibodypositiveencephalitisinadolescent AT junlingwang antidopaminereceptor2antibodypositiveencephalitisinadolescent AT jingli antidopaminereceptor2antibodypositiveencephalitisinadolescent AT huanyang antidopaminereceptor2antibodypositiveencephalitisinadolescent AT boxiao antidopaminereceptor2antibodypositiveencephalitisinadolescent AT guoliangli antidopaminereceptor2antibodypositiveencephalitisinadolescent AT sichen antidopaminereceptor2antibodypositiveencephalitisinadolescent
_version_	1724577329706958848

Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent

Similar Items