Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RN...

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Main Authors: Muneyuki Matsuo, Kensuke Kurihara
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25530-6
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spelling doaj-dae9d84c4b57423fb73dad6a309a93dd2021-09-26T11:45:27ZengNature Publishing GroupNature Communications2041-17232021-09-0112111310.1038/s41467-021-25530-6Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of lifeMuneyuki Matsuo0Kensuke Kurihara1Department of Chemistry, Graduate School of Integrated Sciences for Life, Hiroshima UniversityDepartment of Creative Research, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, MyodaijiCoacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.https://doi.org/10.1038/s41467-021-25530-6
collection DOAJ
language English
format Article
sources DOAJ
author Muneyuki Matsuo
Kensuke Kurihara
spellingShingle Muneyuki Matsuo
Kensuke Kurihara
Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
Nature Communications
author_facet Muneyuki Matsuo
Kensuke Kurihara
author_sort Muneyuki Matsuo
title Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_short Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_full Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_fullStr Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_full_unstemmed Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
title_sort proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.
url https://doi.org/10.1038/s41467-021-25530-6
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AT kensukekurihara proliferatingcoacervatedropletsasthemissinglinkbetweenchemistryandbiologyintheoriginsoflife
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