Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy

Co-delivery of miR-29b and germacrone based on cyclic RGD-modified nanoparticles for liver fibrosis therapy

Abstract Hepatic stellate cells (HSCs) were activated and secreted excessive amounts of extracellular matrix (ECM) proteins during pathogenetic progress of liver fibrosis. Germacrone (GMO) and miR-29b can play an important role in inhibiting growth of HSCs and production of type I collagen. GMO and...

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Bibliographic Details
Main Authors: De Ji, Qiaohan Wang, Qi Zhao, Huangjin Tong, Mengting Yu, Meng Wang, Tulin Lu, Chengxi Jiang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Nanobiotechnology
Subjects:
Hepatic stellate cells
Germacrone
miR-29b
cRGDfK
Liver fibrosis therapy
Online Access:http://link.springer.com/article/10.1186/s12951-020-00645-y

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