| Summary: | Syzygium cumini (L.) Skeels is a famous herbal tree in Myrtaceae family. Antioxidative activity of its ethanolic extract
was determined using DPPH assay and the result showed that S. cumini leaf extract (SLE) exhibited stronger antioxidative
properties than its branch extract (SBE) with IC50 values at 4.58±0.07 and 5.80±0.03 µg/mL, respectively. Moreover, both SLE
and SBE revealed high total phenolic contents which were related to their antioxidative activities. In addition, inhibition of
melanin production was assessed in B16-F10 murine melanoma cells. After 48 hr of incubation at concentrations between 0.06-
1.00 mg/mL, cells exhibited no toxicity and inhibited melanin production. RT-PCR analysis indicated the extracts inhibited the
expression of tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 genes in a dose-dependent manner. The findings reveal
the antioxidative and melanin production inhibitory properties of the S. cumini extracts. In particular, SLE should be further
developed for skin whitening products.
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