Primary Tumor Site Specificity is Preserved in Patient-Derived Tumor Xenograft Models

Primary Tumor Site Specificity is Preserved in Patient-Derived Tumor Xenograft Models

Patient-derived tumor xenograft (PDX) mouse models are widely used for drug screening. The underlying assumption is that PDX tissue is very similar with the original patient tissue, and it has the same response to the drug treatment. To investigate whether the primary tumor site information is well...

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Bibliographic Details
Main Authors: Lei Chen, Xiaoyong Pan, Yu-Hang Zhang, Xiaohua Hu, KaiYan Feng, Tao Huang, Yu-Dong Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Genetics
Subjects:
Patient-derived tumor xenograft
gene expression profile
Monte Carlo feature selection
support vector machine
rule learning algorithm
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00738/full

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