Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach

Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach

Leishmania parasites possess an exceptional oxidant and chemical defense mechanism, involving a very unique small molecular weight thiol, trypanothione (T[SH]2), that helps the parasite to manage its survival inside the host macrophage. The reduced state of T[SH]2 is maintained by NADPH-dependent tr...

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Bibliographic Details
Main Authors: Anurag Kumar, Nutan Chauhan, Shailza Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
leishmaniasis
redox metabolism
trypanothione
Fe/S cluster proteins
glutaredoxin
systems biology
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00015/full

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