Elucidation of the Fanconi Anemia Protein Network in Meoisis and Its Function in the Regulation of Histone Modifications

Elucidation of the Fanconi Anemia Protein Network in Meoisis and Its Function in the Regulation of Histone Modifications

Precise epigenetic regulation of the sex chromosomes is vital for the male germline. Here, we analyze meiosis in eight mouse models deficient for various DNA damage response (DDR) factors, including Fanconi anemia (FA) proteins. We reveal a network of FA and DDR proteins in which FA core factors FAN...

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Bibliographic Details
Main Authors: Kris G. Alavattam, Yasuko Kato, Ho-Su Sin, So Maezawa, Ian J. Kowalski, Fan Zhang, Qishen Pang, Paul R. Andreassen, Satoshi H. Namekawa
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
meiosis
spermatogenesis
germ cells
sex chromosomes
X chromosome
Fanconi anemia
DNA damage response
DNA repair
epigenetics
meiotic sex chromosome inactivation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716313298

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http://www.sciencedirect.com/science/article/pii/S2211124716313298

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