Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway

Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway

Transforming growth factor-β 1 (TGF-β1) is a key mediator in fibrogenesis, and is upregulated and activated in fibrotic diseases. The exact role of TGF-β1-Smad signaling in the progression of silicosis fibrosis is yet to be conclusively determined. Using a Wistar rat silicosis model, we examined whe...

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Bibliographic Details
Main Authors:	Feifei Feng, Nannan Li, Peng Cheng, Huanan Zhang, Hui Wang, Yongbin Wang, Wei Wang
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Tanshinone IIA Silicosis Pulmonary fibrosis Transforming growth factor-beta 1 Smad
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332219352084

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