Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor

Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor

SMAD4, a key regulator of transforming growth factor-β (TGF-β) signaling, plays a major role in cell growth, migration, and apoptosis. In particular, TGF-β/SMAD induces growth arrest, and SMAD4 induces the expression of target genes such as <i>p21WAF1</i> and <i>p15INK4b</i>...

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Bibliographic Details
Main Authors: Nirmal Rajasekaran, Kyoung Song, Jin-Hee Lee, Yun Wei, Özgür Cem Erkin, Hunseok Lee, Young-Kee Shin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
NRF1
SMAD4
transforming growth factor-β
p15INK4b
tumor suppression
Online Access:https://www.mdpi.com/1422-0067/22/11/5595

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