Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Botulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides and synaptic vesicle proteins. The luminal domain 4 (LD4) of the three synaptic vesicle glycoprotein 2 isoforms, SV2A‐C, identified...

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Bibliographic Details
Main Authors: Jasmin Weisemann, Daniel Stern, Stefan Mahrhold, Brigitte G. Dorner, Andreas Rummel
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Toxins
Subjects:
botulinum neurotoxin
rat and human synaptic vesicle glycoprotein 2
gangliosides
binding constant
surface plasmon resonance
Online Access:http://www.mdpi.com/2072-6651/8/5/154

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