Animal models of amyotrophic lateral sclerosis: A comparison of model validity

Animal models of amyotrophic lateral sclerosis: A comparison of model validity

Animal models are necessary to investigate the pathogenic features underlying motor neuron degeneration and for therapeutic development in amyotrophic lateral sclerosis (ALS). Measures of model validity allow for a critical interpretation of results from each model and caution from over-interpretati...

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Bibliographic Details
Main Authors: Jessica R Morrice, Cheryl Y Gregory-Evans, Christopher A Shaw
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
amyotrophic lateral sclerosis; motor neuron degeneration; face validity; construct validity; zebrafish models; mouse models; genetic models; environmental models
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2050;epage=2054;aulast=Morrice

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