Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract

It is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastr...

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Main Authors:	Caterina Vicentini, Matteo Fassan, Edoardo D'Angelo, Vincenzo Corbo, Nicola Silvestris, Gerard J. Nuovo, Aldo Scarpa
Format:	Article
Language:	English
Published:	MDPI AG 2014-02-01
Series:	Molecules
Subjects:	miRNAs neuroendocrine tumors pancreas gastrointestinal tract in situ hybridization
Online Access:	http://www.mdpi.com/1420-3049/19/2/2458

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record_format	Article
spelling	doaj-daafd5bb8353450a937303ce777f58662020-11-24T21:19:59ZengMDPI AGMolecules1420-30492014-02-011922458246810.3390/molecules19022458molecules19022458Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal TractCaterina Vicentini0Matteo Fassan1Edoardo D'Angelo2Vincenzo Corbo3Nicola Silvestris4Gerard J. Nuovo5Aldo Scarpa6ARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, ItalyMedical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari 70124, ItalyComprehensive Cancer Centre, Ohio State University, Columbus, OH 43210, USAARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, ItalyIt is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.http://www.mdpi.com/1420-3049/19/2/2458miRNAsneuroendocrine tumorspancreasgastrointestinal tract in situ hybridization
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Caterina Vicentini Matteo Fassan Edoardo D'Angelo Vincenzo Corbo Nicola Silvestris Gerard J. Nuovo Aldo Scarpa
spellingShingle	Caterina Vicentini Matteo Fassan Edoardo D'Angelo Vincenzo Corbo Nicola Silvestris Gerard J. Nuovo Aldo Scarpa Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract Molecules miRNAs neuroendocrine tumors pancreas gastrointestinal tract in situ hybridization
author_facet	Caterina Vicentini Matteo Fassan Edoardo D'Angelo Vincenzo Corbo Nicola Silvestris Gerard J. Nuovo Aldo Scarpa
author_sort	Caterina Vicentini
title	Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
title_short	Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
title_full	Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
title_fullStr	Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
title_full_unstemmed	Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract
title_sort	clinical application of microrna testing in neuroendocrine tumors of the gastrointestinal tract
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2014-02-01
description	It is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.
topic	miRNAs neuroendocrine tumors pancreas gastrointestinal tract in situ hybridization
url	http://www.mdpi.com/1420-3049/19/2/2458
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Clinical Application of MicroRNA Testing in Neuroendocrine Tumors of the Gastrointestinal Tract

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