Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages.

Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages.

Inflammation and fibrosis are intertwined in multiple disease processes. We have previously found that over-expression of urokinase plasminogen activator in macrophages induces spontaneous macrophage accumulation and fibrosis specific to the heart in mice. Understanding the relationship between infl...

Full description

Bibliographic Details
Main Authors: Jessica Meznarich, Laura Malchodi, Deri Helterline, Stephen A Ramsey, Kate Bertko, Tabitha Plummer, Abigail Plawman, Elizabeth Gold, April Stempien-Otero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594198?pdf=render

Internet

http://europepmc.org/articles/PMC3594198?pdf=render

Similar Items