Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma

Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma

Phosphatidylinositol 3-kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma (HCC) by regulating gene expression. The components and fun...

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Main Author: YU Yuan
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2014-09-01
Series:Linchuang Gandanbing Zazhi
Subjects:
hepatocellular carcinoma; adaptor proteins
signal transducing; revie
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=6022&ClassID=86133911
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spelling doaj-daa30aedfc9a4e9889913c2ca15981612020-11-24T21:35:07ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562014-09-0130995495710.3969/j.issn.1001-5256.2014.09.029Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinomaYU Yuan0Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, ChinaPhosphatidylinositol 3-kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma (HCC) by regulating gene expression. The components and functions of PI3K/Akt/mTOR signaling pathway are briefly described, and the research advances in the action mechanism of PI3K/Akt/mTOR signaling pathway in the progression of HCC and related inhibitors are reviewed. It is disclosed that blocking the PI3K/Akt/mTOR signaling pathway may become a new therapy for HCC.http://www.lcgdbzz.org/qk_content.asp?id=6022&ClassID=86133911hepatocellular carcinoma; adaptor proteinssignal transducing; revie
collection DOAJ
language zho
format Article
sources DOAJ
author YU Yuan
spellingShingle YU Yuan
Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
Linchuang Gandanbing Zazhi
hepatocellular carcinoma; adaptor proteins
signal transducing; revie
author_facet YU Yuan
author_sort YU Yuan
title Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
title_short Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
title_full Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
title_fullStr Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
title_full_unstemmed Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
title_sort role of pi3k/akt/mtor signaling pathway in hepatocellular carcinoma
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2014-09-01
description Phosphatidylinositol 3-kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma (HCC) by regulating gene expression. The components and functions of PI3K/Akt/mTOR signaling pathway are briefly described, and the research advances in the action mechanism of PI3K/Akt/mTOR signaling pathway in the progression of HCC and related inhibitors are reviewed. It is disclosed that blocking the PI3K/Akt/mTOR signaling pathway may become a new therapy for HCC.
topic hepatocellular carcinoma; adaptor proteins
signal transducing; revie
url http://www.lcgdbzz.org/qk_content.asp?id=6022&ClassID=86133911
work_keys_str_mv AT yuyuan roleofpi3kaktmtorsignalingpathwayinhepatocellularcarcinoma
_version_ 1725946523939766272

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