Role of PI3K/Akt/mTOR signaling pathway in hepatocellular carcinoma
Phosphatidylinositol 3-kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma (HCC) by regulating gene expression. The components and fun...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Hepatology
2014-09-01
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| Series: | Linchuang Gandanbing Zazhi |
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| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=6022&ClassID=86133911 |
| Summary: | Phosphatidylinositol 3-kinase, Akt, and the mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma (HCC) by regulating gene expression. The components and functions of PI3K/Akt/mTOR signaling pathway are briefly described, and the research advances in the action mechanism of PI3K/Akt/mTOR signaling pathway in the progression of HCC and related inhibitors are reviewed. It is disclosed that blocking the PI3K/Akt/mTOR signaling pathway may become a new therapy for HCC. |
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| ISSN: | 1001-5256 1001-5256 |