Matrix-Dependent Regulation of AKT in Hepsin-Overexpressing PC3 Prostate Cancer Cells

Matrix-Dependent Regulation of AKT in Hepsin-Overexpressing PC3 Prostate Cancer Cells

The serine-protease hepsin is one of the most prominently overexpressed genes in human prostate carcinoma. Forced expression of the enzyme in mice prostates is associated with matrix degradation, invasive growth, and prostate cancer progression. Conversely, hepsin overexpression in metastatic prost...

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Bibliographic Details
Main Authors: Stephanie M Wittig-Blaich, Lukasz A Kacprzyk, Thorsten Eismann, Melanie Bewerunge-Hudler, Petra Kruse, Eva Winkler, Wolfgang S L Strauss, Raimund Hibst, Rudolf Steiner, Mark Schrader, Daniel Mertens, Holger Sültmann, Rainer Wittig
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800229

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