TGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells

TGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells

Kangjun Zhang,1 Taishi Fang,1 Yajie Shao,2 Yanhui Wu3 1Hepatic Surgery Department, The Third People’s Hospital of Shenzhen, Shenzhen City, Guangdong Province, People’s Republic of China; 2Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Techno...

Full description

Bibliographic Details
Main Authors:	Zhang K, Fang T, Shao Y, Wu Y
Format:	Article
Language:	English
Published:	Dove Medical Press 2021-09-01
Series:	Cancer Management and Research
Subjects:	hepatocellular carcinoma enhancer of zeste homolog 2 transforming growth factor-β metastasis metastasis associated 1 (mta1)-smad7-smad3-sry-box transcription factor 4 (sox4) axis
Online Access:	https://www.dovepress.com/tgf--mta1-smad7-smad3-sox4-ezh2-signaling-axis-promotes-viability-migr-peer-reviewed-fulltext-article-CMAR

Similar Items

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
by: Chao Dai, et al.
Published: (2021-07-01)

Roles of TGFβ signaling Smads in squamous cell carcinoma
by: Han Gangwen, et al.
Published: (2011-12-01)

Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State
by: Linting Huang, et al.
Published: (2020-05-01)

CircATRNL1 activates Smad4 signaling to inhibit angiogenesis and ovarian cancer metastasis via miR‐378
by: Juan Wang, et al.
Published: (2021-04-01)

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival
by: Singh Puneet, et al.
Published: (2011-12-01)

Analysis of the SMAD4 gene in asthma
by: Miletic Aleksandra, et al.
Published: (2014-12-01)

Microglia-Specific Expression of Olfml3 Is Directly Regulated by Transforming Growth Factor β1-Induced Smad2 Signaling
by: Nicolas Neidert, et al.
Published: (2018-07-01)

TGF-β/Smad Signaling in Growth Control of Prostate Epithelial Cells
by: Yang, Jiayi
Published: (2009)

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3
by: Jianning Yao, et al.
Published: (2018-12-01)

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein
by: Tao Yuan, et al.
Published: (2020-01-01)

Assessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research
by: Wosiak A, et al.
Published: (2021-01-01)

Loss of Smad4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis
by: Itatani, Yoshiro
Published: (2014)

Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells
by: M. A. Taipov, et al.
Published: (2014-07-01)

Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro
by: Jianzhou Liu, et al.
Published: (2020-09-01)

Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor
by: Nirmal Rajasekaran, et al.
Published: (2021-05-01)

Identification of Germline Alterations in the Mad-homology 2 (MH2) Domain of SMAD3 and SMAD4 In Breast Cancer Susceptibility
by: Tram, Eric
Published: (2012)

Identification of Germline Alterations in the Mad-homology 2 (MH2) Domain of SMAD3 and SMAD4 In Breast Cancer Susceptibility
by: Tram, Eric
Published: (2012)

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer
by: Marie-Julie Nokin, et al.
Published: (2019-01-01)

Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression
by: Chan, S.-J, et al.
Published: (2022)

miR-21 and miR-155 in the regulation of TGF-β1/SMAD signaling pathway of the line breast cancer cells with different metastatic potential
by: Z. N. Nikiphorova, et al.
Published: (2015-09-01)

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
by: Lidia Ruiz, et al.
Published: (2021-01-01)

SOX2-Upregulated microRNA-30e Promotes the Progression of Esophageal Cancer via Regulation of the USP4/SMAD4/CK2 Axis
by: Yang Yang, et al.
Published: (2021-03-01)

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts
by: Zhaoping Qin, et al.
Published: (2018-04-01)

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma
by: Julie Dardare, et al.
Published: (2020-05-01)

Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis
by: Liu J, et al.
Published: (2020-05-01)

Relationship between Expression of TGF-β1, Smad2, Smad4 and Prognosis  of Patients with Resected Non-small Cell Lung Cancer
by: Mian XIE, et al.
Published: (2015-09-01)

Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals
by: Wei Zhai, et al.
Published: (2018-11-01)

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation
by: Chengcheng Wang, et al.
Published: (2020-07-01)

Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis
by: Yamamoto, Takamasa
Published: (2017)

Non-Canonical Functions of SMAD2 and SMAD3 During Myogenic Differentiation and Fusion
by: Lamarche, Emilie
Published: (2018)

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
by: Jiang Z, et al.
Published: (2019-01-01)

Novel Alternatively Spliced Variants of Smad4 Expressed in TGF-β-Induced EMT Regulating Proliferation and Migration of A549 Cells
by: Wan R, et al.
Published: (2020-03-01)

The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway
by: Li Zhang, et al.
Published: (2018-09-01)

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia
by: Jelena Brkić, et al.
Published: (2020-07-01)

Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells
by: Anwar Abdurahman, et al.
Published: (2019-06-01)

Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway
by: Yuying Yao, et al.
Published: (2019-06-01)

MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis
by: Hanqing Hu, et al.
Published: (2018-04-01)

Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
by: Seung-Yeon Yoo, et al.
Published: (2019-09-01)

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance
by: Sunjida Ahmed, et al.
Published: (2017-01-01)

Smad1 Expression in Follicular Lymphoma
by: Jai Hyang Go
Published: (2015-05-01)