Recent Advances in Molecular Pharmacology of the Histamine Systems: Organic Cation Transporters as a Histamine Transporter and Histamine Metabolism

Recent Advances in Molecular Pharmacology of the Histamine Systems: Organic Cation Transporters as a Histamine Transporter and Histamine Metabolism

Abstract.: Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyl-transferase (HNMT) in bronchus, kidney, and the central nervous system. HNMT seems to be localized in the cytoplasm, but histamine is unable to easily enter the intracellular space. Therefore, two hypotheses...

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Bibliographic Details
Main Authors: Ogasawara Masahito, Yamauchi Kohei, Satoh Yoh-ichi, Yamaji Ryoichi, Inui Kenichi, Jonker Johan W., Schinkel Alfred H., Maeyama Kazutaka
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319344718

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