Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins.

Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins.

BACKGROUND: Recent observational clinical and ex-vivo studies suggest that inflammation and in particular leukocyte activation predisposes to atrial fibrillation (AF). However, whether local binding and extravasation of leukocytes into atrial myocardium is an essential prerequisite for the initiatio...

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Main Authors: Kai Friedrichs, Matti Adam, Lisa Remane, Martin Mollenhauer, Volker Rudolph, Tanja K Rudolph, René P Andrié, Florian Stöckigt, Jan W Schrickel, Thorben Ravekes, Florian Deuschl, Georg Nickenig, Stephan Willems, Stephan Baldus, Anna Klinke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3928425?pdf=render

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http://europepmc.org/articles/PMC3928425?pdf=render

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