Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment

Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment

Piperacillin-Tazobactam is frequently infused in hospitals. The use of a generic version was considered after the out of stock of the brand name Tazocin®. The stability of 4 g of Tazocin® in 120 mL of dextrose 5 % (D5) was demonstrated during 35 days at 5 °C ± 3 °C after freezing (−20 °C) and microw...

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Main Authors: Huvelle Sophie, Godet Marie, Galanti Laurence, Closset Mélanie, Bihin Benoît, Jamart Jacques, Hecq Jean-Daniel
Format: Article
Language:English
Published: De Gruyter 2018-08-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
piperacillin
tazobactam infusion
physicochemical stability
high performance liquid chromatography
microwave freeze-thaw treatment
centralized intravenous admixture services
hospital pharmacy
Online Access:https://doi.org/10.1515/pthp-2018-0014
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spelling doaj-da7065faa22b471eac37ec609b1340602021-10-02T19:03:45ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2018-08-013314315110.1515/pthp-2018-0014Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw TreatmentHuvelle Sophie0Godet Marie1Galanti Laurence2Closset Mélanie3Bihin Benoît4Jamart Jacques5Hecq Jean-Daniel6Medical Laboratory, CHU UCL Namur, Yvoir, BelgiumMedical Laboratory, CHU UCL Namur, Yvoir, BelgiumMedical Laboratory, CHU UCL Namur, Yvoir, BelgiumMedical Laboratory, CHU UCL Namur, Yvoir, BelgiumScientific Support Unit, CHU UCL Namur, Yvoir, BelgiumScientific Support Unit, CHU UCL Namur, Yvoir, BelgiumDepartment of Pharmacy, CHU UCL Namur, Yvoir, BelgiumPiperacillin-Tazobactam is frequently infused in hospitals. The use of a generic version was considered after the out of stock of the brand name Tazocin®. The stability of 4 g of Tazocin® in 120 mL of dextrose 5 % (D5) was demonstrated during 35 days at 5 °C ± 3 °C after freezing (−20 °C) and microwave thawing (FMT). The aim of the study was to investigate and compare the long-term stability of Tazocin® and a generic product in the same conditions.https://doi.org/10.1515/pthp-2018-0014piperacillintazobactam infusionphysicochemical stabilityhigh performance liquid chromatographymicrowave freeze-thaw treatmentcentralized intravenous admixture serviceshospital pharmacy
collection DOAJ
language English
format Article
sources DOAJ
author Huvelle Sophie
Godet Marie
Galanti Laurence
Closset Mélanie
Bihin Benoît
Jamart Jacques
Hecq Jean-Daniel
spellingShingle Huvelle Sophie
Godet Marie
Galanti Laurence
Closset Mélanie
Bihin Benoît
Jamart Jacques
Hecq Jean-Daniel
Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
Pharmaceutical Technology in Hospital Pharmacy
piperacillin
tazobactam infusion
physicochemical stability
high performance liquid chromatography
microwave freeze-thaw treatment
centralized intravenous admixture services
hospital pharmacy
author_facet Huvelle Sophie
Godet Marie
Galanti Laurence
Closset Mélanie
Bihin Benoît
Jamart Jacques
Hecq Jean-Daniel
author_sort Huvelle Sophie
title Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
title_short Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
title_full Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
title_fullStr Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
title_full_unstemmed Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment
title_sort long-term stability comparison between an original and a generic version of piperacillin/tazobactam in dextrose 5 % infusion polyolefin bags at 5 ± 3 °c after microwave freeze-thaw treatment
publisher De Gruyter
series Pharmaceutical Technology in Hospital Pharmacy
issn 2365-2411
2365-242X
publishDate 2018-08-01
description Piperacillin-Tazobactam is frequently infused in hospitals. The use of a generic version was considered after the out of stock of the brand name Tazocin®. The stability of 4 g of Tazocin® in 120 mL of dextrose 5 % (D5) was demonstrated during 35 days at 5 °C ± 3 °C after freezing (−20 °C) and microwave thawing (FMT). The aim of the study was to investigate and compare the long-term stability of Tazocin® and a generic product in the same conditions.
topic piperacillin
tazobactam infusion
physicochemical stability
high performance liquid chromatography
microwave freeze-thaw treatment
centralized intravenous admixture services
hospital pharmacy
url https://doi.org/10.1515/pthp-2018-0014
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