Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment

Long-Term Stability Comparison between an Original and a Generic Version of Piperacillin/Tazobactam in Dextrose 5 % Infusion Polyolefin Bags at 5 ± 3 °C after Microwave Freeze-Thaw Treatment

Piperacillin-Tazobactam is frequently infused in hospitals. The use of a generic version was considered after the out of stock of the brand name Tazocin®. The stability of 4 g of Tazocin® in 120 mL of dextrose 5 % (D5) was demonstrated during 35 days at 5 °C ± 3 °C after freezing (−20 °C) and microw...

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Bibliographic Details
Main Authors: Huvelle Sophie, Godet Marie, Galanti Laurence, Closset Mélanie, Bihin Benoît, Jamart Jacques, Hecq Jean-Daniel
Format: Article
Language:English
Published: De Gruyter 2018-08-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
piperacillin
tazobactam infusion
physicochemical stability
high performance liquid chromatography
microwave freeze-thaw treatment
centralized intravenous admixture services
hospital pharmacy
Online Access:https://doi.org/10.1515/pthp-2018-0014
Description
Summary:Piperacillin-Tazobactam is frequently infused in hospitals. The use of a generic version was considered after the out of stock of the brand name Tazocin®. The stability of 4 g of Tazocin® in 120 mL of dextrose 5 % (D5) was demonstrated during 35 days at 5 °C ± 3 °C after freezing (−20 °C) and microwave thawing (FMT). The aim of the study was to investigate and compare the long-term stability of Tazocin® and a generic product in the same conditions.
ISSN:2365-2411
2365-242X

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