High-Dose Cyclophosphamide Administration Orchestrates Phenotypic and Functional Alterations of Immature Dendritic Cells and Regulates Th Cell Polarization

High-Dose Cyclophosphamide Administration Orchestrates Phenotypic and Functional Alterations of Immature Dendritic Cells and Regulates Th Cell Polarization

High-dose cyclophosphamide (CTX) inhibits the immune response. Dendritic cells (DCs) are professional antigen presenting cells (APCs) with a crucial role in initiating immune responses and sustaining immune tolerance. The relative contribution of DCs to immunosuppression induced by high-dose CTX is...

Full description

Bibliographic Details
Main Authors: Lei Bao, Changfu Hao, Juan Wang, Di Wang, Youliang Zhao, Yiping Li, Wu Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
cyclophosphamide
immature dendritic cells
antigen uptake capacity
T cell priming
Th polarization
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00775/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00775/full

Similar Items