Combining paclitaxel with ABT-263 has a synergistic effect on paclitaxel resistant prostate cancer cells.

Combining paclitaxel with ABT-263 has a synergistic effect on paclitaxel resistant prostate cancer cells.

We assessed the capability of paclitaxel, one of the taxanes, to induce death in two prostate cancer lines, LNCaP and PC3. Paclitaxel drove an apoptotic pathway in LNCaP, but not in PC3 cells, in response to G2/M arrest. An examination of the levels of anti-apoptotic proteins revealed that Bcl-xl wa...

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Bibliographic Details
Main Authors: Chihuei Wang, Shih-Bo Huang, Min-Chi Yang, Yi-Tsen Lin, I-Hung Chu, Ya-Ni Shen, Yueh-Ho Chiu, Shao-Hung Hung, Lin Kang, Yi-Ren Hong, Chung-Hwan Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0120913

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