Understanding Immune Thrombocytopenia: Looking Out of the Box

Understanding Immune Thrombocytopenia: Looking Out of the Box

The pathogenesis of immune thrombocytopenia (ITP) is increasingly being elucidated, and its etiology is becoming more frequently identified, leading to a diagnostic shift from primary to secondary ITP. The overlap between autoimmunity, immunodeficiency, and cancer is evident, implying more interdisc...

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Bibliographic Details
Main Authors: Alexandra Schifferli, Franco Cavalli, Bertrand Godeau, Howard A. Liebman, Mike Recher, Paul Imbach, Thomas Kühne
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Medicine
Subjects:
immune thrombocytopenia
ITP syndrome
secondary ITP
autoimmunity
immunodeficiency
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.613192/full
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spelling doaj-da64c461a33f4284bc63867435d6cd672021-06-24T05:41:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-06-01810.3389/fmed.2021.613192613192Understanding Immune Thrombocytopenia: Looking Out of the BoxAlexandra Schifferli0Alexandra Schifferli1Franco Cavalli2Bertrand Godeau3Howard A. Liebman4Mike Recher5Paul Imbach6Thomas Kühne7Thomas Kühne8Department of Hematology/Oncology, University Children's Hospital Basel, Basel, SwitzerlandIntercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, SwitzerlandLymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, SwitzerlandCentre de Référence des Cytopénies Auto-Immunes de l'Adulte, Service de Médecine Interne, CHU Henri Mondor, AP-HP, Université Paris-Est Créteil, Créteil, FranceJane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United StatesMedical Outpatient Clinic and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital and University Basel, Basel, SwitzerlandIntercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, SwitzerlandDepartment of Hematology/Oncology, University Children's Hospital Basel, Basel, SwitzerlandIntercontinental Cooperative Immune thrombocytopenia (ITP) Study Group, Basel, SwitzerlandThe pathogenesis of immune thrombocytopenia (ITP) is increasingly being elucidated, and its etiology is becoming more frequently identified, leading to a diagnostic shift from primary to secondary ITP. The overlap between autoimmunity, immunodeficiency, and cancer is evident, implying more interdisciplinarity in daily care. This mini-review is based on an expert meeting on ITP organized by the Intercontinental Cooperative ITP Study Group and presents the challenges of hematologists in understanding and investigating “out of the box” concepts associated with ITP.https://www.frontiersin.org/articles/10.3389/fmed.2021.613192/fullimmune thrombocytopeniaITP syndromesecondary ITPautoimmunityimmunodeficiencycancer
collection DOAJ
language English
format Article
sources DOAJ
author Alexandra Schifferli
Alexandra Schifferli
Franco Cavalli
Bertrand Godeau
Howard A. Liebman
Mike Recher
Paul Imbach
Thomas Kühne
Thomas Kühne
spellingShingle Alexandra Schifferli
Alexandra Schifferli
Franco Cavalli
Bertrand Godeau
Howard A. Liebman
Mike Recher
Paul Imbach
Thomas Kühne
Thomas Kühne
Understanding Immune Thrombocytopenia: Looking Out of the Box
Frontiers in Medicine
immune thrombocytopenia
ITP syndrome
secondary ITP
autoimmunity
immunodeficiency
cancer
author_facet Alexandra Schifferli
Alexandra Schifferli
Franco Cavalli
Bertrand Godeau
Howard A. Liebman
Mike Recher
Paul Imbach
Thomas Kühne
Thomas Kühne
author_sort Alexandra Schifferli
title Understanding Immune Thrombocytopenia: Looking Out of the Box
title_short Understanding Immune Thrombocytopenia: Looking Out of the Box
title_full Understanding Immune Thrombocytopenia: Looking Out of the Box
title_fullStr Understanding Immune Thrombocytopenia: Looking Out of the Box
title_full_unstemmed Understanding Immune Thrombocytopenia: Looking Out of the Box
title_sort understanding immune thrombocytopenia: looking out of the box
publisher Frontiers Media S.A.
series Frontiers in Medicine
issn 2296-858X
publishDate 2021-06-01
description The pathogenesis of immune thrombocytopenia (ITP) is increasingly being elucidated, and its etiology is becoming more frequently identified, leading to a diagnostic shift from primary to secondary ITP. The overlap between autoimmunity, immunodeficiency, and cancer is evident, implying more interdisciplinarity in daily care. This mini-review is based on an expert meeting on ITP organized by the Intercontinental Cooperative ITP Study Group and presents the challenges of hematologists in understanding and investigating “out of the box” concepts associated with ITP.
topic immune thrombocytopenia
ITP syndrome
secondary ITP
autoimmunity
immunodeficiency
cancer
url https://www.frontiersin.org/articles/10.3389/fmed.2021.613192/full
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