Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis

ObjectiveDendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs. In contrast, CD141+ DCs and plasmacytoid DCs (pDCs) have not been systematically examined, at least in earl...

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Bibliographic Details
Main Authors: Faye A. H. Cooles, Amy E. Anderson, Andrew Skelton, Arthur G. Pratt, Mariola S. Kurowska-Stolarska, Iain McInnes, Catharien M. U. Hilkens, John D. Isaacs
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
early rheumatoid arthritis
plasmacytoid dendritic cells
conventional dendritic cells
tolerance
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00755/full

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