Clinical features of cardiac lesion in patients with generalized sarcoidosis

The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial inf...

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Main Authors:	E.N. POPOVA, L.A. STRIZHAKOV, V.I. SHOLOMOVA, A.B. PONOMAREV, S.V. MOISEEV, M.U. BROVKO, I.B. BONDARENKO, L.A. PONOMAREVA, V.V. FOMIN
Format:	Article
Language:	Russian
Published:	"Consilium Medicum" Publishing house 2018-01-01
Series:	Терапевтический архив
Subjects:	sarcoidosis extrapulmonary manifestation of sarcoidosis cardiomyopathy cardiac rhythm disorder atherosclerosis
Online Access:	http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?element

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record_format	Article
spelling	doaj-da44676063154f5597aa82bed3b2f8c32020-11-25T01:29:38Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-01-01901545910.26442/terarkh201890154-59Clinical features of cardiac lesion in patients with generalized sarcoidosisE.N. POPOVA0L.A. STRIZHAKOV1V.I. SHOLOMOVA2A.B. PONOMAREV3S.V. MOISEEV4M.U. BROVKO5I.B. BONDARENKO6L.A. PONOMAREVA7V.V. FOMIN8I.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaI.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, RussiaThe article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immunosuppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice. http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?elementsarcoidosisextrapulmonary manifestation of sarcoidosiscardiomyopathycardiac rhythm disorderatherosclerosis
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN
spellingShingle	E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN Clinical features of cardiac lesion in patients with generalized sarcoidosis Терапевтический архив sarcoidosis extrapulmonary manifestation of sarcoidosis cardiomyopathy cardiac rhythm disorder atherosclerosis
author_facet	E.N. POPOVA L.A. STRIZHAKOV V.I. SHOLOMOVA A.B. PONOMAREV S.V. MOISEEV M.U. BROVKO I.B. BONDARENKO L.A. PONOMAREVA V.V. FOMIN
author_sort	E.N. POPOVA
title	Clinical features of cardiac lesion in patients with generalized sarcoidosis
title_short	Clinical features of cardiac lesion in patients with generalized sarcoidosis
title_full	Clinical features of cardiac lesion in patients with generalized sarcoidosis
title_fullStr	Clinical features of cardiac lesion in patients with generalized sarcoidosis
title_full_unstemmed	Clinical features of cardiac lesion in patients with generalized sarcoidosis
title_sort	clinical features of cardiac lesion in patients with generalized sarcoidosis
publisher	"Consilium Medicum" Publishing house
series	Терапевтический архив
issn	0040-3660 2309-5342
publishDate	2018-01-01
description	The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Extrapulmonary symptoms regressed when conducting immunosuppressive therapy. Discusses modern aspects of diagnosis of sarcoidosis in clinical practice.
topic	sarcoidosis extrapulmonary manifestation of sarcoidosis cardiomyopathy cardiac rhythm disorder atherosclerosis
url	http://ter-arkhiv.ru/en/archive/2018/vol-90_1_2018/klinicheskie-osobennosti-porazheniya-serdtsa-pri-generalizovannom-sarkoidoze_526/?element
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Clinical features of cardiac lesion in patients with generalized sarcoidosis

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