Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study

Objective Non-alcoholic fatty liver disease (NAFLD) is associated with microalbuminuria (MA) in patients with diabetes/pre-diabetes. Whether this association is mediated by blood glucose and blood pressure (BP) remains unclear. This study investigated whether liver fat content (LFC) was associated w...

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Main Authors: Xiaoming Li, Hui Ma, Mingfeng Xia, Hongmei Yan, Wanyuan He, Huandong Lin, Nai Qing Zhao
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/6/e044237.full
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spelling doaj-da34d92390cb47f9ba4131eeb4889ae42021-08-07T17:03:22ZengBMJ Publishing GroupBMJ Open2044-60552021-06-0111610.1136/bmjopen-2020-044237Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional studyXiaoming Li0Hui Ma1Mingfeng Xia2Hongmei Yan3Wanyuan He4Huandong Lin5Nai Qing Zhao6Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartment of Ultrasonography, Zhongshan Hospital Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai, ChinaStatistics, School of Public Health, Fudan University, Shanghai, ChinaObjective Non-alcoholic fatty liver disease (NAFLD) is associated with microalbuminuria (MA) in patients with diabetes/pre-diabetes. Whether this association is mediated by blood glucose and blood pressure (BP) remains unclear. This study investigated whether liver fat content (LFC) was associated with MA in a normotensive and non-diabetic population.Design A cross-sectional substudy.Settings LFC was determined from the hepatic/renal echogenicity ratio at ultrasound. MA was defined as an albumin-to-creatinine ratio (ACR) of 30–300 µg/mg (early- morning urine sample). Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate LFC as a predictor of MA.Participants Between May 2010 and June 2011, this cross-sectional, community-based study enrolled residents from Shanghai (China), aged ≥40 years and with normal glucose tolerance and BP.Results A total of 550 residents (median age, 57 years; 174 men) were enrolled and stratified according to LFC quartiles. ACR (p<0.001) and MA prevalence (p=0.012) increased across the LFC quartiles. Multivariable logistic regression showed that the OR for MA (per SD increase in LFC) was 1.840 (95% CI 1.173 to 2.887, p=0.008) after adjustment for potential confounders including age, gender, waist-hip ratio, blood urea nitrogen, systolic and diastolic BP, fasting blood glucose, postprandial glucose, low-density lipoprotein-cholesterol, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, estimated glomerular filtration rate and lipid-lowering drugs. The ROC analysis revealed that the optimal LFC cut-off value for predicting MA was 6.82%.Conclusion LFC is independently associated with MA in normotensive, euglycaemic middle-aged and elderly Chinese individuals. Screening for MA in people with NAFLD might facilitate early intervention to minimise kidney disease risk.https://bmjopen.bmj.com/content/11/6/e044237.full
collection DOAJ
language English
format Article
sources DOAJ
author Xiaoming Li
Hui Ma
Mingfeng Xia
Hongmei Yan
Wanyuan He
Huandong Lin
Nai Qing Zhao
spellingShingle Xiaoming Li
Hui Ma
Mingfeng Xia
Hongmei Yan
Wanyuan He
Huandong Lin
Nai Qing Zhao
Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
BMJ Open
author_facet Xiaoming Li
Hui Ma
Mingfeng Xia
Hongmei Yan
Wanyuan He
Huandong Lin
Nai Qing Zhao
author_sort Xiaoming Li
title Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
title_short Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
title_full Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
title_fullStr Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
title_full_unstemmed Liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic Chinese population: a community-based, cross-sectional study
title_sort liver fat content is independently associated with microalbuminuria in a normotensive, euglycaemic chinese population: a community-based, cross-sectional study
publisher BMJ Publishing Group
series BMJ Open
issn 2044-6055
publishDate 2021-06-01
description Objective Non-alcoholic fatty liver disease (NAFLD) is associated with microalbuminuria (MA) in patients with diabetes/pre-diabetes. Whether this association is mediated by blood glucose and blood pressure (BP) remains unclear. This study investigated whether liver fat content (LFC) was associated with MA in a normotensive and non-diabetic population.Design A cross-sectional substudy.Settings LFC was determined from the hepatic/renal echogenicity ratio at ultrasound. MA was defined as an albumin-to-creatinine ratio (ACR) of 30–300 µg/mg (early- morning urine sample). Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate LFC as a predictor of MA.Participants Between May 2010 and June 2011, this cross-sectional, community-based study enrolled residents from Shanghai (China), aged ≥40 years and with normal glucose tolerance and BP.Results A total of 550 residents (median age, 57 years; 174 men) were enrolled and stratified according to LFC quartiles. ACR (p<0.001) and MA prevalence (p=0.012) increased across the LFC quartiles. Multivariable logistic regression showed that the OR for MA (per SD increase in LFC) was 1.840 (95% CI 1.173 to 2.887, p=0.008) after adjustment for potential confounders including age, gender, waist-hip ratio, blood urea nitrogen, systolic and diastolic BP, fasting blood glucose, postprandial glucose, low-density lipoprotein-cholesterol, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, estimated glomerular filtration rate and lipid-lowering drugs. The ROC analysis revealed that the optimal LFC cut-off value for predicting MA was 6.82%.Conclusion LFC is independently associated with MA in normotensive, euglycaemic middle-aged and elderly Chinese individuals. Screening for MA in people with NAFLD might facilitate early intervention to minimise kidney disease risk.
url https://bmjopen.bmj.com/content/11/6/e044237.full
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