Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias

Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias

Impaired axonal development and degeneration underlie debilitating neurodegenerative diseases including hereditary spastic paraplegia, a large group of inherited diseases. Hereditary spastic paraplegia is caused by retrograde degeneration of the long corticospinal tract axons, leading to progressive...

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Bibliographic Details
Main Authors: Yongchao Mou, Xue-Jun Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
hereditary spastic paraplegia; axonal degeneration; mitochondrial dynamics; fission; fusion; dynamin-related protein 1; mitochondrial dysfunction; induced pluripotent stem cells
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=574;epage=577;aulast=Mou

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