Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses

BackgroundPerturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barri...

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Bibliographic Details
Main Authors: Maha Khalaf, Toby Scott-Ward, Adam Causer, Zoe Saynor, Anthony Shepherd, Dariusz Górecki, Anthony Lewis, David Laight, Janis Shute
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
endothelium
CFTR
cystic fibrosis
inflammation
oxidative stress
cell signaling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00879/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00879/full

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