Metal- and acid-free, TBN-mediated direct CH nitration of arenes
A metal-free, acid-free, direct and eco-friendly nitration methodology has been developed. A tert-butyl nitrite efficiently promotes the direct CH nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demonstrated in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | Journal of Saudi Chemical Society |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S131961031930002X |
| Summary: | A metal-free, acid-free, direct and eco-friendly nitration methodology has been developed. A tert-butyl nitrite efficiently promotes the direct CH nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demonstrated in gram-scale nitration of crown ether and mono nitration of Sesamin. A plausible free radical mechanism is proposed based on detailed experimental observations. Keywords: Metal-free, Acid-free, Tert-butyl nitrite, Nitration, Electron-rich arenes |
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| ISSN: | 1319-6103 |