Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevate...

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Bibliographic Details
Main Authors: Hyun ah Yoon, Paul F. Riska, Ruchika Jain, Cariane Morales, Liise-anne Pirofski
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Medical Mycology Case Reports
Subjects:
Cryptococcal meningoencephalitis
Cryptococcosis
HIV infection
Inflammatory response
Host immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753921000038
Description
Summary:Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4+ T cell counts, which likely contributed to greater inflammation.
ISSN:2211-7539

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