Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles

Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles

Preformed albumin corona of albumin-nonselective nanoparticles (NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However, very few studies have concerned the preformed albumin corona of albumin-selective NPs. Herein, we report a novel type of al...

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Main Authors: Zhenbao Li, Dan Li, Wenjuan Zhang, Peng Zhang, Qiming Kan, Jin Sun
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Asian Journal of Pharmaceutical Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618303970
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spelling doaj-da2291a2b1ff4801b99e91e781646ddd2020-11-25T00:00:45ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762019-01-011415262Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticlesZhenbao Li0Dan Li1Wenjuan Zhang2Peng Zhang3Qiming Kan4Jin Sun5Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China; The College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, ChinaWuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, ChinaDepartment of Pharmacy, Shenyang Pharmaceutical University, ChinaDepartment of Pharmacology, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China; Corresponding author: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 24 23986325.Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China; Corresponding author: Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Tel.: +86 24 23986325.Preformed albumin corona of albumin-nonselective nanoparticles (NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However, very few studies have concerned the preformed albumin corona of albumin-selective NPs. Herein, we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate (SA) onto PLGA NPs (SP NPs) surface, taking albumin-nonselective PLGA NPs as control. PLGA NPs and SP NPs were prepared by emulsion-solvent evaporation method and the resultant NPs were in spherical shape with an average diameter around 180 nm. The corresponding albumin-coating PLGA NPs (PLGA@BSA NPs) and albumin-coating SP NPs (SP@BSA NPs) were formulated by incubating SP NPs or PLGA NPs with bovine serum albumin solution, respectively. The impact of albumin corona on particle characteristics, stability, photothermal effect, cytotoxicity, cell uptake, spheroid penetration and pharmacokinetics was investigated. In line with previous findings of preformed albumin coating, PLGA@BSA NPs exhibited higher stability, cytotoxicity, cell internalization and spheroid penetration performances in vitro, and longer blood circulation time in vivo than those of albumin-nonselective PLGA NPs, but albumin-selective SP NPs is capable of achieving a comparable in vitro and in vivo performances with both SP@BSA NPs and PLGA@BSA NPs. Our results demonstrate that SA decorated albumin-selective NPs pave a versatile avenue for optimizing nanoparticulate delivery without preformed albumin corona. Keywords: Preformed albumin corona, Albumin-nonselective PLGA NPs, Albumin-selective SP NPs, In vitro and in vivo performanceshttp://www.sciencedirect.com/science/article/pii/S1818087618303970
collection DOAJ
language English
format Article
sources DOAJ
author Zhenbao Li
Dan Li
Wenjuan Zhang
Peng Zhang
Qiming Kan
Jin Sun
spellingShingle Zhenbao Li
Dan Li
Wenjuan Zhang
Peng Zhang
Qiming Kan
Jin Sun
Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
Asian Journal of Pharmaceutical Sciences
author_facet Zhenbao Li
Dan Li
Wenjuan Zhang
Peng Zhang
Qiming Kan
Jin Sun
author_sort Zhenbao Li
title Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
title_short Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
title_full Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
title_fullStr Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
title_full_unstemmed Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
title_sort insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
publisher Elsevier
series Asian Journal of Pharmaceutical Sciences
issn 1818-0876
publishDate 2019-01-01
description Preformed albumin corona of albumin-nonselective nanoparticles (NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However, very few studies have concerned the preformed albumin corona of albumin-selective NPs. Herein, we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate (SA) onto PLGA NPs (SP NPs) surface, taking albumin-nonselective PLGA NPs as control. PLGA NPs and SP NPs were prepared by emulsion-solvent evaporation method and the resultant NPs were in spherical shape with an average diameter around 180 nm. The corresponding albumin-coating PLGA NPs (PLGA@BSA NPs) and albumin-coating SP NPs (SP@BSA NPs) were formulated by incubating SP NPs or PLGA NPs with bovine serum albumin solution, respectively. The impact of albumin corona on particle characteristics, stability, photothermal effect, cytotoxicity, cell uptake, spheroid penetration and pharmacokinetics was investigated. In line with previous findings of preformed albumin coating, PLGA@BSA NPs exhibited higher stability, cytotoxicity, cell internalization and spheroid penetration performances in vitro, and longer blood circulation time in vivo than those of albumin-nonselective PLGA NPs, but albumin-selective SP NPs is capable of achieving a comparable in vitro and in vivo performances with both SP@BSA NPs and PLGA@BSA NPs. Our results demonstrate that SA decorated albumin-selective NPs pave a versatile avenue for optimizing nanoparticulate delivery without preformed albumin corona. Keywords: Preformed albumin corona, Albumin-nonselective PLGA NPs, Albumin-selective SP NPs, In vitro and in vivo performances
url http://www.sciencedirect.com/science/article/pii/S1818087618303970
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