Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitte...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
|
Series: | International Journal of Alzheimer's Disease |
Online Access: | http://dx.doi.org/10.1155/2012/974013 |
id |
doaj-da1fdb0805174863b34260f1e20f373d |
---|---|
record_format |
Article |
spelling |
doaj-da1fdb0805174863b34260f1e20f373d2020-11-24T23:41:29ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-80242090-02522012-01-01201210.1155/2012/974013974013Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative StressPuchchakayala Goverdhan0Akina Sravanthi1Thati Mamatha2Centre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaCentre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaCentre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may themselves trigger the expression of inflammatory mediators, such as cyclooxygenase 2 (COX-2). In the present study, the effects of Meloxicam, Selegiline, and coadministration of these drugs on scopolamine-induced learning and memory impairments in mice were investigated. Rectangular maze test, Morris water maze test, Locomotor activity, and Pole climbing test were conducted to evaluate the learning and memory parameters. Various biochemical parameters such as acetylcholinesterase(AChE), TBARS assay, catalase activity, and DPPH assay were also assessed. The present study demonstrates that Meloxicam, Selegiline, and co-administration of these test drugs had potential therapeutic effects on improving the antiamnesic activity in mice through inhibiting lipid peroxidation, augmenting endogenous antioxidant enzymes, and decreasing acetylcholinesterase activity in brain. The memory enhancing capacity of the drugs was very significant when compared to disease control (P<0.001).http://dx.doi.org/10.1155/2012/974013 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Puchchakayala Goverdhan Akina Sravanthi Thati Mamatha |
spellingShingle |
Puchchakayala Goverdhan Akina Sravanthi Thati Mamatha Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress International Journal of Alzheimer's Disease |
author_facet |
Puchchakayala Goverdhan Akina Sravanthi Thati Mamatha |
author_sort |
Puchchakayala Goverdhan |
title |
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress |
title_short |
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress |
title_full |
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress |
title_fullStr |
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress |
title_full_unstemmed |
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress |
title_sort |
neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress |
publisher |
Hindawi Limited |
series |
International Journal of Alzheimer's Disease |
issn |
2090-8024 2090-0252 |
publishDate |
2012-01-01 |
description |
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may themselves trigger the expression of inflammatory mediators, such as cyclooxygenase 2 (COX-2). In the present study, the effects of Meloxicam, Selegiline, and coadministration of these drugs on scopolamine-induced learning and memory impairments in mice were investigated. Rectangular maze test, Morris water maze test, Locomotor activity, and Pole climbing test were conducted to evaluate the learning and memory parameters. Various biochemical parameters such as acetylcholinesterase(AChE), TBARS assay, catalase activity, and DPPH assay were also assessed. The present study demonstrates that Meloxicam, Selegiline, and co-administration of these test drugs had potential therapeutic effects on improving the antiamnesic activity in mice through inhibiting lipid peroxidation, augmenting endogenous antioxidant enzymes, and decreasing acetylcholinesterase activity in brain. The memory enhancing capacity of the drugs was very significant when compared to disease control (P<0.001). |
url |
http://dx.doi.org/10.1155/2012/974013 |
work_keys_str_mv |
AT puchchakayalagoverdhan neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress AT akinasravanthi neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress AT thatimamatha neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress |
_version_ |
1725507027791249408 |