Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitte...

Full description

Bibliographic Details
Main Authors: Puchchakayala Goverdhan, Akina Sravanthi, Thati Mamatha
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.1155/2012/974013
id doaj-da1fdb0805174863b34260f1e20f373d
record_format Article
spelling doaj-da1fdb0805174863b34260f1e20f373d2020-11-24T23:41:29ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-80242090-02522012-01-01201210.1155/2012/974013974013Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative StressPuchchakayala Goverdhan0Akina Sravanthi1Thati Mamatha2Centre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaCentre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaCentre for Neurodegenerative Disease and Aging Research Department of Pharmacology, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal 506001, IndiaAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may themselves trigger the expression of inflammatory mediators, such as cyclooxygenase 2 (COX-2). In the present study, the effects of Meloxicam, Selegiline, and coadministration of these drugs on scopolamine-induced learning and memory impairments in mice were investigated. Rectangular maze test, Morris water maze test, Locomotor activity, and Pole climbing test were conducted to evaluate the learning and memory parameters. Various biochemical parameters such as acetylcholinesterase(AChE), TBARS assay, catalase activity, and DPPH assay were also assessed. The present study demonstrates that Meloxicam, Selegiline, and co-administration of these test drugs had potential therapeutic effects on improving the antiamnesic activity in mice through inhibiting lipid peroxidation, augmenting endogenous antioxidant enzymes, and decreasing acetylcholinesterase activity in brain. The memory enhancing capacity of the drugs was very significant when compared to disease control (P<0.001).http://dx.doi.org/10.1155/2012/974013
collection DOAJ
language English
format Article
sources DOAJ
author Puchchakayala Goverdhan
Akina Sravanthi
Thati Mamatha
spellingShingle Puchchakayala Goverdhan
Akina Sravanthi
Thati Mamatha
Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
International Journal of Alzheimer's Disease
author_facet Puchchakayala Goverdhan
Akina Sravanthi
Thati Mamatha
author_sort Puchchakayala Goverdhan
title Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
title_short Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
title_full Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
title_fullStr Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
title_full_unstemmed Neuroprotective Effects of Meloxicam and Selegiline in Scopolamine-Induced Cognitive Impairment and Oxidative Stress
title_sort neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress
publisher Hindawi Limited
series International Journal of Alzheimer's Disease
issn 2090-8024
2090-0252
publishDate 2012-01-01
description Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with localized loss of neurons mainly in the hippocampus and basal forebrain, with diminished level of central cholinergic neurotransmitter-acetylcholine and also reported to be associated with accumulation of ubiquitinated proteins in neuronal inclusions and also with signs of inflammation. In these disorders, the abnormal protein aggregates may themselves trigger the expression of inflammatory mediators, such as cyclooxygenase 2 (COX-2). In the present study, the effects of Meloxicam, Selegiline, and coadministration of these drugs on scopolamine-induced learning and memory impairments in mice were investigated. Rectangular maze test, Morris water maze test, Locomotor activity, and Pole climbing test were conducted to evaluate the learning and memory parameters. Various biochemical parameters such as acetylcholinesterase(AChE), TBARS assay, catalase activity, and DPPH assay were also assessed. The present study demonstrates that Meloxicam, Selegiline, and co-administration of these test drugs had potential therapeutic effects on improving the antiamnesic activity in mice through inhibiting lipid peroxidation, augmenting endogenous antioxidant enzymes, and decreasing acetylcholinesterase activity in brain. The memory enhancing capacity of the drugs was very significant when compared to disease control (P<0.001).
url http://dx.doi.org/10.1155/2012/974013
work_keys_str_mv AT puchchakayalagoverdhan neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress
AT akinasravanthi neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress
AT thatimamatha neuroprotectiveeffectsofmeloxicamandselegilineinscopolamineinducedcognitiveimpairmentandoxidativestress
_version_ 1725507027791249408