EZH2 promotes the expression of LPA1 by mediating microRNA-139 promoter methylation to accelerate the development of ovarian cancer

EZH2 promotes the expression of LPA1 by mediating microRNA-139 promoter methylation to accelerate the development of ovarian cancer

Abstract Background It has been known that ovarian cancer (OC) is a leading cause for women mortality globally. We aimed to analyze the underlying mechanism supporting that enhancer of zeste homolog 2 (EZH2) affected the development of OC via the involvement of microRNA-139 (miR-139)/transforming gr...

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Bibliographic Details
Main Authors: Dongbo Wu, Fanglan Wu, Birong Li, Wei Huang, Donglian Wang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cancer Cell International
Subjects:
Ovarian cancer
Tumor growth
Enhancer of zeste 2 polycomb repressive complex 2 subunit
microRNA-139
Online Access:http://link.springer.com/article/10.1186/s12935-020-01622-z

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