MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response.

BACKGROUND:Aberrant expression of DNA repair proteins is associated with poor survival in cancer patients. We investigated the combined expression of MRE11 and ATM as a predictive marker of response to radiotherapy in rectal cancer. METHODS:MRE11 and ATM expression were examined in tumor samples fro...

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Main Authors: Vincent Ho, Liping Chung, Maxine Revoltar, Stephanie H Lim, Thein-Ga Tut, Askar Abubakar, Chris J Henderson, Wei Chua, Weng Ng, Mark Lee, Paul De Souza, Matthew Morgan, C Soon Lee, Joo-Shik Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5145179?pdf=render