Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact and traffic through subcellular sites to serve these essential functions is unknown. We show that RhopH is synthesized as a s...

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Bibliographic Details
Main Authors: Marc A Schureck, Joseph E Darling, Alan Merk, Jinfeng Shao, Geervani Daggupati, Prakash Srinivasan, Paul Dominic B Olinares, Michael P Rout, Brian T Chait, Kurt Wollenberg, Sriram Subramaniam, Sanjay A Desai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
malaria
cryo-EM
nutrient uptake
erythrocyte invasion
protein structure
pore-forming proteins
Online Access:https://elifesciences.org/articles/65282

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