Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity

Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of...

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Main Authors:	Freddy H. Havaldar, Abhay R. Patil
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2008/394737

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spelling	doaj-da0587d315c141cab8af75185264a0882020-11-25T00:02:47ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102008-01-015234735410.1155/2008/394737Syntheses of 1, 2, 4 Triazole Derivatives and their Biological ActivityFreddy H. Havaldar0Abhay R. Patil1Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai - 400 001, IndiaNadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai - 400 001, IndiaCyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR, 1H NMR and Mass spectra. The compounds have also been screened for their biological activity.http://dx.doi.org/10.1155/2008/394737
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Freddy H. Havaldar Abhay R. Patil
spellingShingle	Freddy H. Havaldar Abhay R. Patil Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity E-Journal of Chemistry
author_facet	Freddy H. Havaldar Abhay R. Patil
author_sort	Freddy H. Havaldar
title	Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity
title_short	Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity
title_full	Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity
title_fullStr	Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity
title_full_unstemmed	Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity
title_sort	syntheses of 1, 2, 4 triazole derivatives and their biological activity
publisher	Hindawi Limited
series	E-Journal of Chemistry
issn	0973-4945 2090-9810
publishDate	2008-01-01
description	Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR, 1H NMR and Mass spectra. The compounds have also been screened for their biological activity.
url	http://dx.doi.org/10.1155/2008/394737
work_keys_str_mv	AT freddyhhavaldar synthesesof124triazolederivativesandtheirbiologicalactivity AT abhayrpatil synthesesof124triazolederivativesandtheirbiologicalactivity
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Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity

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