The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment

Objectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memo...

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Main Authors: Xudong Li, Miaoxin Shen, Yi Jin, Shuhong Jia, Zhi Zhou, Ziling Han, Xiangfei Zhang, Xiaopeng Tong, Jinsong Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Psychiatry
Subjects:
MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685965/full
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spelling doaj-d9efa73b37094485aa63968e7e48ea992021-07-16T06:47:12ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.685965685965The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive ImpairmentXudong Li0Xudong Li1Miaoxin Shen2Yi Jin3Shuhong Jia4Zhi Zhou5Ziling Han6Xiangfei Zhang7Xiaopeng Tong8Jinsong Jiao9Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaMedical School, Xizang Minzu University, Xianyang, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaMedical School, Xizang Minzu University, Xianyang, ChinaDepartment of Neurology, China-Japan Friendship Hospital, Beijing, ChinaObjectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics.Methods: A total of 236 patients with MCI and 85 healthy controls were included. One hundred nine amnestic MCI-multiple domains (amMCI), 38 amnestic MCI-single domain (asMCI), 36 non-amnestic MCI-multiple domains (namMCI), and 53 non-amnestic MCI-single domain (nasMCI) patients were diagnosed. All participants were evaluated with the cognitive assessments and imaging features including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and cerebral atrophy according to a standard procedure.Results: The patients with amMCI, namMCI, and nasMCI had more high-grade basal ganglia EPVS compared with healthy controls, while the percentages of high-grade basal ganglia EPVS in the patients with amMCI were also more than those in patients with asMCI, namMCI, and nasMCI. There were more high-grade centrum semiovale EPVS in patients with amMCI in comparison with all other groups. The patients with amMCI and namMCI had more percentages of severe deep and periventricular WMH and deep CMBs compared with healthy controls. All MCI groups had higher scores of the medial temporal lobe atrophy than healthy controls, whereas the scores of the amMCI group were also higher than those of the namMCI and nasMCI groups.Conclusions: There were varied neuroimaging features of CSVD including cerebral atrophy in different MCI groups, which meant that vascular mechanism contributed to the prodromal stage of dementia.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685965/fullmild cognitive impairmentcerebral small vessel diseaseMRIwhite matter hyperintensityenlarged perivascular spacescerebral microbleed
collection DOAJ
language English
format Article
sources DOAJ
author Xudong Li
Xudong Li
Miaoxin Shen
Yi Jin
Shuhong Jia
Zhi Zhou
Ziling Han
Xiangfei Zhang
Xiaopeng Tong
Jinsong Jiao
spellingShingle Xudong Li
Xudong Li
Miaoxin Shen
Yi Jin
Shuhong Jia
Zhi Zhou
Ziling Han
Xiangfei Zhang
Xiaopeng Tong
Jinsong Jiao
The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
Frontiers in Psychiatry
mild cognitive impairment
cerebral small vessel disease
MRI
white matter hyperintensity
enlarged perivascular spaces
cerebral microbleed
author_facet Xudong Li
Xudong Li
Miaoxin Shen
Yi Jin
Shuhong Jia
Zhi Zhou
Ziling Han
Xiangfei Zhang
Xiaopeng Tong
Jinsong Jiao
author_sort Xudong Li
title The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
title_short The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
title_full The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
title_fullStr The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
title_full_unstemmed The Effect of Cerebral Small Vessel Disease on the Subtypes of Mild Cognitive Impairment
title_sort effect of cerebral small vessel disease on the subtypes of mild cognitive impairment
publisher Frontiers Media S.A.
series Frontiers in Psychiatry
issn 1664-0640
publishDate 2021-07-01
description Objectives: Cerebral small vessel disease (CSVD) is the most common vascular cause of dementia, and mild cognitive impairment (MCI) is an intermediate state between dementia and normal cognitive aging. The present study investigated the main imaging features of CSVD on different MCI subtypes in memory clinics.Methods: A total of 236 patients with MCI and 85 healthy controls were included. One hundred nine amnestic MCI-multiple domains (amMCI), 38 amnestic MCI-single domain (asMCI), 36 non-amnestic MCI-multiple domains (namMCI), and 53 non-amnestic MCI-single domain (nasMCI) patients were diagnosed. All participants were evaluated with the cognitive assessments and imaging features including white matter hyperintensity (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and cerebral atrophy according to a standard procedure.Results: The patients with amMCI, namMCI, and nasMCI had more high-grade basal ganglia EPVS compared with healthy controls, while the percentages of high-grade basal ganglia EPVS in the patients with amMCI were also more than those in patients with asMCI, namMCI, and nasMCI. There were more high-grade centrum semiovale EPVS in patients with amMCI in comparison with all other groups. The patients with amMCI and namMCI had more percentages of severe deep and periventricular WMH and deep CMBs compared with healthy controls. All MCI groups had higher scores of the medial temporal lobe atrophy than healthy controls, whereas the scores of the amMCI group were also higher than those of the namMCI and nasMCI groups.Conclusions: There were varied neuroimaging features of CSVD including cerebral atrophy in different MCI groups, which meant that vascular mechanism contributed to the prodromal stage of dementia.
topic mild cognitive impairment
cerebral small vessel disease
MRI
white matter hyperintensity
enlarged perivascular spaces
cerebral microbleed
url https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685965/full
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