| Summary: | Corn peptide promotes glucagon-like peptide-1 release in type 2 diabetic animals, while wheat peptide increases pro-inflammatory cytokine response in type 1 diabetic patients. However, the effect of a mixture of corn and wheat peptide on the initiation and the development of type 1 diabtes remains unclear. Corn peptide reduced the blood glucose in wheat peptide-evoked diabetic NOD mice. A mixture of corn and wheat peptide significantly delayed the initiation and decreased the incidence of diabetes in NOD mice. In addition to the improved oral glucose tolerance, level of interleukin (IL)-6 and the insulitis score were decreased, while β-cell areas and IL-10 gene expression were increased via treatment with this peptide mixture. Meanwhile, serine and histidine levels in the serum were significantly increased in this peptide mixture treated NOD mice. Our data suggested that a mixture of corn and wheat peptide could prevent diabetes in NOD mice.
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