Severe dengue is associated with consumption of von Willebrand factor and its cleaving enzyme ADAMTS-13.

Severe dengue is associated with consumption of von Willebrand factor and its cleaving enzyme ADAMTS-13.

Thrombocytopenia, bleeding and plasma leakage are cardinal features of severe dengue. Endothelial cell activation with exocytosis of Weibel-Palade bodies (WPBs) may play an etiological role in this condition.In a cohort of 73 Indonesian children with dengue hemorrhagic fever (DHF), of which 30 with...

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Bibliographic Details
Main Authors: Kis Djamiatun, Andre J A M van der Ven, Philip G de Groot, Sultana M H Faradz, D Hapsari, Wil M V Dolmans, Silvie Sebastian, Rob Fijnheer, Quirijn de Mast
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3341341?pdf=render

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