Comparative effectiveness of original and generic losartan in patients with arterial hypertension

• Main Authors: S. V. Nedogoda, T. A. Chalyabi, V. V. Tsoma, U. A. Brel, G. V. Mazina
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2007-12-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: arterial hypertension; losartan; generics
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1390
• ISSN: 1728-8800; 2619-0125

Aim. To compare clinical effectiveness and tolerability of original (Cozaar®) and generic (Lozap®) losartan in high and very high-risk patients with Stage I-II arterial hypertension (AH). Material and methods. This blind, randomized (envelope method), parallel study included 40 patients, 20 subjects in each group. After 14-day wash-out period, the participants were administered Cozaar® or Lozap® (50 mg/d; 1 tablet in the morning) for 3 months. Results. Cozaar® and Lozap® reduced systolic blood pressure (SBP) by 11,6% and 12,0% (р<0,05), respectively, diastolic BP (DBP) – by 8,3% and 8,2% (р<0,05), respectively (office measurement data). According to 24-hour BP monitoring data, T/P for SBP was 67,1% and 66,3% in Cozaar® and Lozap® groups, respectively (p<0,05). Both agents similarly reduced left ventricular posterior wall thickness, carotid-femoral and carotid-radial pulse wave rates – by 16,6%, 9,9%, 12,8% vs 16,6%, 10,1%, and 12,2%, respectively. Conclusion. Original and generic losartan medications were similar by antihypertensive activity and effects on surrogate end-points.