Recent Progress Concerning the <i>N</i>-Arylation of Indoles

Recent Progress Concerning the <i>N</i>-Arylation of Indoles

This review summarizes the current state-of-the-art procedures in terms of the preparation of <i>N</i>-arylindoles. After a short introduction, the transition-metal-free procedures available for the <i>N</i>-arylation of indoles are briefly discussed. Then, the nickel-catalyz...

Full description

Bibliographic Details
Main Authors: Petr Oeser, Jakub Koudelka, Artem Petrenko, Tomáš Tobrman
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
<i>N</i>-arylation
indole
Buchwald–Hartwig amination
Ullmann condensation
Chan–Lam coupling
Online Access:https://www.mdpi.com/1420-3049/26/16/5079
Description
Summary:This review summarizes the current state-of-the-art procedures in terms of the preparation of <i>N</i>-arylindoles. After a short introduction, the transition-metal-free procedures available for the <i>N</i>-arylation of indoles are briefly discussed. Then, the nickel-catalyzed and palladium-catalyzed <i>N</i>-arylation of indoles are both discussed. In the next section, copper-catalyzed procedures for the <i>N</i>-arylation of indoles are described. The final section focuses on recent findings in the field of biologically active <i>N</i>-arylindoles.
ISSN:1420-3049

Similar Items